The "Handbook of Analysis of Oligonucleotides and Related Products" (2011) is an essential reference manual for the application of current and emerging analytical techniques for the analysis of oligonucleotides in support of research and development.

Dr. Bernhard Noll is co-author of the Chapter on Capillary Electrophoresis.





Chapter 3: Separation Strategies for Oligonucleotides. Bernhard Noll and Ingo Roehl. Analytical Characterization of Oligonucleotides and their Related Substances. Edited by David Elder, George Okafo and Mike Webb. Publisher: ILM Publications, in press.

Purification of small interfering RNA using non-denaturing anion-exchange chromatography. Noll, Bernhard; Seiffert, Stephan; Hertel, Frank; Debelak, Harald; Hadwiger, Philipp; Vornlocher, Hans-Peter; Roehl, Ingo Nucleic Acid Therapeutics (2011), 21 (6): 383-393

Characterization of Small Interfering RNA by Non-Denaturing Ion-Pair Reversed-Phase Liquid ChromatographyNoll, Bernhard; Seiffert, Stephan; Vornlocher, Hans-Peter; Roehl, Ingo Journal of Chromatography A (2011) 1218(33), 5609-17

Characterization of Side Reactions During the Annealing of Small Interfering RNAs. Seiffert, Stephan; Debelak, Harald; Hadwiger, Philipp; Jahn-Hofmann, Kerstin; Roehl, Ingo; Vornlocher, Hans-Peter; Noll, Bernhard Analytical Biochemistry (2011), 414(1), 47-57

Dual or triple activation of TLR7, TLR8 and/or TLR9 by single-stranded oligonucleotides.
Forsbach, Alexandra; Samulowitz, Ulrike; Völp, Kirsten; Hofmann, Hans-Peter; Noll, Bernhard; Tluk, Sybille; Schmitz, Claudia; Wader, Tanja; Müller, Christian; Podszuweit, Anja; Lohner, Angela; Curdt, Rainer; Uhlmann, Eugen; Vollmer, Jörg  Nucleic Acid Therapeutics (2011), in press

Quality Aspects of Oligonucleotide Drug Development. Part 1: Specifications for Active Pharmaceutical Ingredients (API).  Daniel Capaldi , Kathy Ackley, Doug Brooks, Judy Carmody, Nallaperum Chidambaram, Ken Draper, Rao Kambhampati, Matthias Kretschmer, Daren Levin, James McArdle, Bernhard Noll, Ramesh Raghavachari, Ipsita Roymoulik, B. P. (Bob) Sharma, Rene Thuermer, Fran Wincott; white paper, presented at the 3rd Oligonucleotide-based Therapeutics Conference (2010), Bethesda, MA, USA, in press

A Novel Class of Immune-Stimulatory CpG Oligodeoxynucleotides Unifies High Potency in Type I Interferon Induction with Preferred Structural Properties.  Samulowitz, Ulrike; Weber, Markus; Weeratna, Risini; Uhlmann, Eugen; Noll, Bernhard; Krieg, Arthur M.; Vollmer, Joerg.  Oligonucleotides (2010), 20(2), 93-101. ISSN: 1545-4576.

Identification and Quantification of GC-rich Oligodeoxynucleotides in Tissue Extracts by Capillary Gel Electrophoresis.  Noll, Bernhard O.; Debelak, Harald; Uhlmann, Eugen.  Journal of Chromatography, B: Analytical Technologies in the Biomedical and Life Sciences (2007), 847(2), 153-161.  Publisher: Elsevier B.V., ISSN: 1570-0232. 

Quantification of Oligodeoxynucleotides in Human Plasma With a Novel Hybridization Assay Offers Greatly Enhanced Sensitivity Over Capillary Gel Electrophoresis.  Efler, S. M.; Zhang, L.; Noll, B. O.; Uhlmann, E.; Davis, H. L.  Oligonucleotides  (2005),  15(2),  119-131.  ISSN: 1545-4576. 

Biodistribution and Metabolism of Immunostimulatory Oligodeoxynucleotide CPG 7909 in Mouse and Rat Tissues Following Subcutaneous Administration.  Noll, Bernhard O.; McCluskie, Michael J.; Sniatala, Tanja; Lohner, Angela; Yuill, Stephanie; Krieg, Arthur M.; Schetter, Christian; Davis, Heather L.; Uhlmann, Eugen.  Biochemical Pharmacology (2005), 69(6), 981-991.  ISSN: 0006-2952. 

C-Class CpG ODN: Sequence Requirements and Characterization of Immunostimulatory Activities on mRNA Level.  Jurk, Marion; Schulte, Bettina; Kritzler, Andrea; Noll, Bernhard; Uhlmann, Eugen; Wader, Tanja; Schetter, Christian; Krieg, Arthur M.; Vollmer, Joerg.    Immunobiology  (2004),  209(1-2),  141-154.  ISSN: 0171-2985. 

Heat Shock Protein-Peptide Complexes for Use in Vaccines.  Heike, Michael; Noll, Bernhard; Meyer zum Bueschenfelde, Karl-Hermann.  Journal of Leukocyte Biology  (1996),  60(2),  153-158.  ISSN: 0741-5400.


Immunostimulatory P-Class Oligonucleotide Formulations for Use in Treating Diseases and as Vaccine Adjuvants.  Uhlmann, Eugen; Vollmer, Joerg; Krieg, Arthur M.; Samulowitz, Ulrike; Noll, Bernhard O.  PCT Int. Appl.  (2007), 111 pp. WO 2007095316 A2 20070823 

Modulation of TLR-Mediated Immune Responses Using Adaptor Oligonucleotides.  Jurk, Marion; Vollmer, Joerg; Krieg, Arthur M.; Uhlmann, Eugen; Noll, Bernhard O.  PCT Int. Appl.  (2007), 113 pp. WO 2007038720 A2 20070405 

CpG Immunostimulatory Nucleic Acids and Oligonucleotide Analogs for Enhancing Immune Response of Vaccines Against Infection, Allergy and Cancer.  Uhlmann, Eugen; Vollmer, Joerg; Krieg, Arthur M.; Noll, Bernhard O.  PCT Int. Appl.  (2005), 113 pp. WO 2005042018 A2 20050512    

Screening for Immunostimulatory DNA Functional Modifiers.  Noll, Bernhard O.; Schetter, Christian; Krieg, Arthur M.  PCT Int. Appl. (2000), 95 pp.  WO 2000067023 A1 20001109


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