NB|Chem.de was founded in 2011 to assist bio/pharmaceutical companies and academic institutions with the development of promising new therapeutic molecules. Our goal is to provide strategic guidance on complex Chemistry, Manufacturing and Controls (CMC) issues surrounding novel technologies.
Our scientific background covers immunology as well as analytical and chemical sciences. We can offer many years of experience in pre-clinical and clinical development of biopharmaceutical therapeutics.
An image of the Moon Jelly is used by NB|Chem.de as a beautiful illustration of the synergy between chemistry, physics and biology in a living organism.
This picture of Aurelia aurita was taken at the Aquazoo in Düsseldorf, Germany
About the Moon Jelly:
Aurelia aurita (moon jelly, moon jellyfish, common jellyfish, saucer jelly) is one of a group of more than ten morphologically nearly identical jellyfish species in the genus Aurelia. The medusa is rompe translucent, usually about 25–40 cm in diameter, and can be recognized by its four horseshoe-shaped gonads that are easily seen through the top of the bell. It feeds by collecting medusae, plankton and mollusks with its mucusy bell nematocyst-laden tentacles; like other jellies it primarily drifts with the current, even when it is swimming.
The green fluorescent protein (GFP) is a protein composed of 238 amino acid residues (26.9 kDa) that exhibits bright green fluorescence when exposed to blue light. Many marine organisms have similar green fluorescent proteins, although GFP traditionally refers to the protein first isolated from the jellyfish Aequorea victoria. The GFP from A. victoria has a major excitation peak at a wavelength of 395 nm and a minor one at 475 nm. Its emission peak is at 509 nm, which is in the lower green portion of the visible spectrum. The fluorescence quantum yield (QY) of GFP is 0.79.
In cell and molecular biology, the GFP gene is frequently used as a reporter of expression. In modified forms it has been used to make biosensors, and many animals have been created that express GFP as a proof-of-concept that a gene can be expressed throughout a given organism. The GFP gene can be introduced into organisms and maintained in their genome through breeding, injection with a viral vector, or cell transformation. To date, the GFP gene has been introduced and expressed in many bacteria, yeast and other fungi, fish (such as zebrafish), plant, fly, and mammalian cells, including human.
Martin Chalfie, Osamu Shimomura, and Roger Y. Tsien were awarded the 2008 Nobel Prize in Chemistry for their discovery and development of the green fluorescent protein.
(Paragraph on Jellyfish and GFP was taken and modified from Wikipedia.org)